Medicinal Chemistry's Latest Developments: A Thorough Review

Abstract

Medicinal chemistry has evolved to completely integrate developments in molecular biology, artificial intelligence (AI), and computational modeling for better drug development and discovery. Recent innovations such as gene editing based on CRISPR, targeted therapeutics, green chemical techniques, AI-driven drug design, and nanomedicine are discussed in this paper. The integration of AI and machine learning accelerated drug discovery by combining better molecular design, improved pharmacokinetic optimization, and reduced development costs. Green chemistry concepts have enabled the creation of environmentally friendly synthesis techniques that have decreased hazardous waste. The bioavailability of nanomedicine has brought a revolution in drug delivery through targeted therapeutic approaches. Tailored medicine powered by pharmacogenomics allows for more precise and effective treatments. However, drug resistance, high production costs, and complexity in regulatory compliance remain problems despite these advancements. Future studies should focus on developing gene-editing methods, increasing the applications of nanotechnology, and strengthening AI models in order to improve therapeutic efficacy and sustainability. Altogether, these developments hold promises for safer, more efficient, and more readily available pharmaceutical treatments that will shape medicinal chemistry in the future.